ENHANCE

The Issue

Development and evaluation of a targeted, integrated, coherent and people-centred approach to the management of multimorbidity in South African primary healthcare

The ENHANCE study aims to co-produce and evaluate a scalable health system intervention to improve care for people living with multiple long-term conditions (MLTCs) in South Africa. It seeks to balance clinical evidence with patient needs, community preferences, and local health system realities. The project is a collaboration between UKZN, King’s College London, and the Knowledge Translation Unit at the University of Cape Town.

The Intervention

UKZN leads the formative research and KwaZulu-Natal arm of a cluster randomised control trial testing an integrated intervention. This includes improved health promotion materials, unified clinical guidelines for managing common MLTCs, and household-level support from community health workers using a patient-held diary.

The Impact

By integrating clinical, community, and system-based approaches, ENHANCE aims to strengthen people-centred care for those with multiple chronic conditions. The findings will inform national strategies to deliver more coordinated, effective, and equitable primary health care in South Africa.

Project Information

Project Leads

Prof. Inge Petersen

Co-Leads

WORK PACKAGE FOUR CO-LEADS:
Prof. Inge Petersen
Assoc. Prof. Andre Van Rensburg
Prof. Mosa Moshabela

Project Team

Dr. Tasneem Kathree
Prof. Zamasomi Luvuno
Prof. Arvin Bhana
Londiwe Mthethwa-Bhengu
Sanah Bucibo
One Selohilwe
Gcina Radebe
Assoc. Prof. Bernhard Gaede

Project Timeline

Sept 2021 - August 2025

Funders

UK NIHR (Right)

Collaborators and Partners

Kings College London
University of Cape Town
KwaZulu-Natal Department of Health
Western Cape Department of Health

Project Keywords

Multimorbidity
Person-centred care
Hybrid trial